The database can be searched according to germline gene, clinical category, identifiers or sequence.

Germline Gene Usage

These options represent the variable region germline gene use, organized by family. All genes are specified using the IMGT nomenclature. Alleles of individual genes are considered to be identical.

Clinical Category

Sequences in the database are divided into three main categories.

• AL-PCD: Plasma Cell Dyscrasia (PCD) and AL Amyloidosis.
• Other PCD: This includes other PCDs such as Multiple Myeloma and Light Chain Deposition Disease.
• Non-PCD: All other LC sequences, including normal repertoire, autoimmune, and anti-infectious LCs. These sequences are retained for comparison but we recommend that larger and more diverse sets of sequences are used for research.

Each subcategory is divided into subcategories representing distinct clinical entities.

Sequences with identified problems such as in-frame stop codons and many missing residues are excluded by default. To include these sequences, please check the box.

Sample Sources

Sequences can be searched by their molecule type, nucleotide or protein.

Identifiers

Please separate accession numbers, PMIDs or clone/isolate/patient IDs by spaces. No sequences are excluded from these searches.

BLAST search

Please enter a protein or nucleotide sequence for a BLAST query against the entire database.

The results page presents the set of sequences that matches your query. 20, 50, 100, or 1000 sequences can be shown at one time. Sequences can be sorted by accession number, patient ID, or germline gene usage (variable, joining, constant). Germline gene names are given using their IMGT gene name (IGKV1-12) and allele (*01). Click on the sequence name to learn more about that sequence.

Selection

Next to each sequence is a check box. Selected sequences can be removed from the current set, downloaded or aligned using the buttons at the bottom of the page.