For general information about the project, visit the Welcome page.

HISTORY

AL-Base was envisioned by Dr. David Seldin, who was the Director of the Amyloidosis Center. Dr. Seldin passed away in 2015 and AL-Base is dedicated to his memory.

The original site was built by Kip Bodi and launched in 2008. It is described in a publication in the journal Amyloid . Core data included 238 light chains sequenced by Boston University.

The site was relaunched in 2021 following a complete rebuild. Additional sequences have been deposited and new functions added.

DATABASE INFORMATION

AL-Base has been totally rebuilt with ASP.Net Core. The previous versions were written in Ruby.

CONTRIBUTING TO AL-BASE

We encourage investigators to deposit sequences in NCBI, ENA or other repositories for use by the community. Please contact the AL-Base team to inform us of deposited or published light chain sequences that can be included in AL-Base.

CITING AL-BASE

Please cite the original manuscript: Bodi et al., Amyloid, 2009 .

ACKNOWLEDGMENTS

AL-Base is made possible by the generosity of patients and researchers who are willing to share their sequences with the research community.

The creators of the database would like to thank the following people:

Tatiana Prokaeva and Gareth Morgan, current Principle Investigators;

Axin Hua, current site design, building and maintenance;

Biostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, website hosting and management

We thank Drs. Paola Rognoni, Francesca Lavatelli and Mario Nuvolone from the Amyloidosis Research and Treatment Center at University of Pavia, Italy; Dr. Raymond Comenzo from the Tufts University School of Medicine; and Dr. Stefan Schönland from the Amyloidosis Center at Heidelberg University Hospital, Germany; and Drs. Christophe Sirac and Vincent Javaugue from the Université de Limoges, France, for helping us to collect and compile sequences generated from their Centers.

Original project participants:

David Seldin, original Principal Investigator;

Kip Bodi, original site design and construction;

Maurya Eberhard, creative input;

Tatiana Prokaeva, and Brian Spencer, AL patient LC sequence generation;

Avrum Spira and David Ulrich, technical support;

Benjamin Forbes, sequence checking and categorization.

Financial support

AL-Base was originally supported by NIH grant P01 HL68705 to Boston University. Ongoing development is supported by the Wildflower Trust and the Amyloid Research Fund of the Boston University Chobanian and Avedisian School of Medicine.