AL-BASE LATEST NEWS
Update 2024
New search and alignment tools have been added and the database expanded with additional sequences. We are grateful to Dr. Mario Nuvolone from the University of Pavia, Dr. Raymond Comenzo from the Tufts University School of Medicine, and Drs. Christophe Sirac and Vincent Javaugue from the Université de Limoges for assistance with sequences from their laboratories.
Update 2023
Over 700 light chain sequences from multiple myeloma clones from the CoMMpass study have been added to the database. Details are provided in our publication: Nau et al. 2023. Access to the CoMMpass study data was provided by the Multiple Myeloma Research Foundation.
Update 2021
AL-Base has been updated to a new server and database architecture. Launch date: August 31, 2021.
This improved version of AL-Base:
contains unique light chain sequences associated with AL amyloidosis (n=556) and other plasma cell dyscrasias (n=242) including 177 new light chain sequences associated with AL amyloidosis, multiple myeloma, light chain deposition disease, and POEMS syndrome obtained from the literature;
features the elimination of redundant entries, where multiple copies of the same sequence are present; and
has a more streamlined nomenclature where possible (e.g. Myeloma replaced with MM).
Most core AL-Base functionality remains unchanged, although the underlying code has been completely re-built. The advanced sequence analyses are still in development. The release of an enhanced version of AL-Base, incorporating more analytical tools, is anticipated in 2022.
The new architecture was built in the ASP.Net Core framework by Dr. Axin Hua at the Boston University School of Public Health Biostatistics and Epidemiology Data Analytics Center (BEDAC). New sequences were identified by Drs. Tatiana Prokaeva and Gareth Morgan of the Amyloidosis Center at Boston University School of Medicine. We would like to thank Drs. Paola Rognoni and Francesca Lavatelli from the Amyloidosis Research and Treatment Center at University of Pavia, Italy and Professor Stefan Schönland from the Amyloidosis Center at Heidelberg University Hospital, Germany for helping us to collect and compile sequences generated from their Centers.
We welcome feedback about the updated AL-Base version. Please let us know if you have any issues.